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1

Differences in the Induction of Macrophage Cytotoxicity by the Specific T Lymphocyte Factor, Specific Macrophage Arming Factor (SMAF), and the Lymphokine, Macrophage Arming Factor (SMAF), and the Lymphokine, Macrophage Activating Factor (MAF)

De Groot, Jan W., De Weger, Roelof A., Vandebriel, Rob J., Den Otter, Willem

Journal:

Year:

1989

Language:

english

File:

PDF, 1.52 MB

english, 1989

2

Optimal regimes for local IL-2 tumour therapy

Willem Den Otter, Jan Willem De Groot, Monique R. Bernsen, A. Peter M. Heintz, Riks Maas, Gerrit Jan Hordijk, F. W. Graham Hill, Wim R. Klein, E. Joost Ruitenberg, Victor P. M. G. Rutten

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 524 KB

english, 1996

3

Second primary tumors in patients with hereditary retinoblastoma: A register-based follow-up study, 1945–1994

Annette C. Moll, Saskia M. Imhof, Lex M. Bouter, D. Joop Kuik, Willem Den Otter, P. Dick Bezemer, Jan Willem Koten, Karel E. W. P. Tan

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 510 KB

english, 1996

4

Local low-dose interleukin-2 induces systemic immunity when combined with radiotherapy of cancer. A pre-clinical study

Linda A. Everse, Ingrid B. Renes, Ina M. Jürgenliemk-Schulz, Derk H. Rutgers, Monique R. Bernsen, Hub F.J. Dullens, Willem Den Otter, Jan J. Battermann

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 58 KB

english, 1997

5

Therapeutic efficacy of IL-2-loaded hydrogels in a mouse tumor model

Cornelis J. De Groot, Jenny A. Cadée, Jan-Willem Koten, Wim E. Hennink, Willem Den Otter

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 669 KB

english, 2002

6

Dualistic effects of cis-diammine-dichloro-platinum on the anti-tumor efficacy of subsequently applied recombinant interleukin-2 therapy: A tumor-dependent phenomenon

Moniquc R. Bernsen, A. Peter M. Heintz, Harrold J. J. Van Barungen, Alike W. Van Der Velden, Hub F. J. Dullens, Willem Den Otter

Journal:

International Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 616 KB

english, 1993

7

Effect of immunomodulators on specific tumor immunity induced by liposome-encapsulated tumor-associated antigens

Joep J. Bergers, Willem Den Otter, Hub F. J. Dullens, Jan Willem De Groot, Peter A. Steerenberg, Margreet P. G. Filius, Daan J. A. Crommelin

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 784 KB

english, 1994

8

PEG-IL-2 therapy of advanced cancer in the guinea pig. Impact of the primary tumor and beneficial effect of cyclopphosphamide

Lianne T. M. Balemans, Peter A. Steerenberg, Frank J. Koppenhagen, Bas H. A. Kremer, Pieter H. M. De Mulder, Anke M. E. Claessen, Rik J. Scheper, Willem Den Otter

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 754 KB

english, 1994

9

Growth advantage of human leiomyoma cells compared to normal smooth-muscle cells due to enhanced sensitivity toward insulin-like growth factor I

Leo T. M. Van Der Ven, Ton Gloudemans, Paul J. M. Roholl, Sylvia C. Van Buul-Offers, Bellinda A. Bladergroen, Marij J. P. Welters, John S. Sussenbach, Willem Den Otter

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

10

Phosphodiesters in saponified extracts of human breast and colon tumors using 31P magnetic resonance spectroscopy

Thomas E. Merchant, Dainius Characiejus, John N. Kasimos, Willem Den Otter, Louis W. Gierke, Thomas Glonek

Journal:

Magnetic Resonance in Medicine

Year:

1992

Language:

english

File:

PDF, 576 KB

english, 1992

11

T cells and tumors

Riks A Maas, Hub F.J Dullens, Willem Den Otter

Journal:

Immunology Today

Year:

1992

Language:

english

File:

PDF, 260 KB

english, 1992

12

In vitro biocompatibility of biodegradable dextran-based hydrogels tested with human fibroblasts

Cees J De Groot, Marja J.A Van Luyn, Welmoed N.E Van Dijk-Wolthuis, Jenny A Cadée, Josée A Plantinga, Willem Den Otter, Wim E Hennink

Journal:

Year:

2001

Language:

english

File:

PDF, 317 KB

english, 2001

13

Specific tumoricidal activity of cytotoxic macrophages and cytotoxic lymphocytes

Hub F. J. Dullens, Sjef Schakenraad, Ad Oostdijk, Wim Vuist, Martin Maas, Willem Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1986

Language:

english

File:

PDF, 795 KB

english, 1986

14

Tumor cells do not arise frequently

Journal:

Cancer Immunology, Immunotherapy

Year:

1985

Language:

english

File:

PDF, 446 KB

english, 1985

15

Immune reactivity in SL2 lymphoma-bearing mice compared with SL2-immunized mice

Roel A. Weger, Bert Wilbrink, Roel M. P. Moberts, Dennis Mans, Ralph Oskam, Willem Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1987

Language:

english

File:

PDF, 2.40 MB

english, 1987

16

Immune surveillance and natural resistance: an evaluation

Journal:

Cancer Immunology, Immunotherapy

Year:

1986

Language:

english

File:

PDF, 985 KB

english, 1986

17

Reply

Journal:

Cancer Immunology, Immunotherapy

Year:

1986

Language:

english

File:

PDF, 68 KB

english, 1986

18

Letter to the editors

Margaret L. Kripke, Willem Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1986

Language:

english

File:

PDF, 98 KB

english, 1986

19

Macrophage infiltration in tumors and tumor-surrounding tissue: influence of serotonin and sensitized lymphocytes

Gerrit Los, Roel A. Weger, Désirée T. W. M. Berg, Ron Sakkers, Willem Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1988

Language:

english

File:

PDF, 1.55 MB

english, 1988

20

Critical factors for liposome-incorporated tumour-associated antigens to induce protective tumour immunity to SL2 lymphoma cells in mice

Joep J. Bergers, Willem Den Otter, Hub F. J. Dullens, Jan Willem De Groot, Peter A. Steerenberg, Monique W. H. Mimpen, Daan J. A. Crommelin

Journal:

Cancer Immunology, Immunotherapy

Year:

1993

Language:

english

File:

PDF, 1.20 MB

english, 1993

21

Specific tumor memory induced by polyethylene-glycol-modified interleukin-2 requires both helper and cytotoxic T cells

Lianne T. M. Balemans, Peter A. Steerenberg, Bas H. A. Kremer, Frank J. Koppenhagen, Pieter H. M. De Mulder, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1995

Language:

english

File:

PDF, 742 KB

english, 1995

22

Initial immunochemical characterization of specific macrophage-arming factor

Roel A. De Weger, Rob J. Vandebriel, Hans Slager, Dennis Mans, Henk Van Loveren, Bert Wilbrink, Hub F. J. Dullens, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1989

Language:

english

File:

PDF, 953 KB

english, 1989

23

Production of specific macrophage-arming factor precedes cytotoxic T lymphocyte activity in vivo during tumor rejection

Hub F. J. Dullens, Roel A. De Weger, Martin Van Der Maas, Piet J. Den Besten, Rob J Vandebriel, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1989

Language:

english

File:

PDF, 826 KB

english, 1989

24

Non-cytotoxic asialo-GM1-positive cells exert antimetastatic activity

Leon Strzadala, Ianusz Rak, Ewa Ziolo, Maria Paprocka, Czeslaw Radzikowski, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1989

Language:

english

File:

PDF, 828 KB

english, 1989

25

Interleukin-2 in cancer treatment: Disappointing or (still) promising? A review

Riks A. Maas, Hub F. J. Dullens, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1993

Language:

english

File:

PDF, 980 KB

english, 1993

26

Intratumoral low-dose interleukin-2 induces rejection of distant solid tumour

Riks A. Maas, D. Henk, J. Van Weering, Hub F. J. Dullens, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1991

Language:

english

File:

PDF, 1.48 MB

english, 1991

27

Reconstituted membranes of tumour cells (proteoliposomes) induce specific protection to murine lymphoma cells

Joep J. Bergers, Willem Den Otter, Jan Willem De Groot, Adriana W. De Blois, Hub F. J. Dullens, Peter A. Steerenberg, Daan J. A. Crommelin

Journal:

Cancer Immunology, Immunotherapy

Year:

1992

Language:

english

File:

PDF, 1.08 MB

english, 1992

28

Mechanisms of tumour rejection in the murine DBA/2-SL2 concomitant immunity system

Dainius Characiejus, Hub F. J. Dullens, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1990

Language:

english

File:

PDF, 1.53 MB

english, 1990

29

Therapy of bovine ocular squamous-cell carcinoma with local doses of interleukin-2: 67% complete regressions after 20 months of follow-up

F. W. Willem Den Otter, Graham Hill, Wim R. Klein, Jan Willem Koten, Peter A. Steerenberg, Pieter H. M. De Mulder, Christopher Rhode, Rachel Stewart, Joop A. J. Faber, E. Joost Ruitenberg, Victor P. M

Journal:

Cancer Immunology, Immunotherapy

Year:

1995

Language:

english

File:

PDF, 530 KB

english, 1995

30

Histological analysis of IL-2 induced regression of murine solid SL2-tumors

Riks A. Maas, Hub F. J. Dullens, D. Henk, J. Van Weering, Hanneke J. I. De Mik, Jan -Willem Koten, R. J. Belger, Willem Den Otter

Journal:

Year:

1993

Language:

english

File:

PDF, 1.67 MB

english, 1993

31

The mechanism of regression of solid SL2 lymphosarcoma after local IL-2 therapy

Anton H. Baselmans, Jan-Willem Koten, Jan J. Battermann, Jaap E. Van Dijk, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

2002

Language:

english

File:

PDF, 435 KB

english, 2002

32

Therapeutic effect of a single peritumoural dose of IL-2 on transplanted murine breast cancer

Ekaterina V. Moiseeva, Irina B. Merkulova, Caspaar Bijleveld, Jan-Willem Koten, Anatoly I. Miroshnikov, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

2003

Language:

english

File:

PDF, 310 KB

english, 2003

33

Mechanisms of macrophage cytotoxicity in IL-2 and IL-12 mediated tumour regression

Agnieszka Masztalerz, Nico Van Rooijen, Willem Den Otter, Linda A. Everse

Journal:

Cancer Immunology, Immunotherapy

Year:

2003

Language:

english

File:

PDF, 313 KB

english, 2003

34

Further development of local IL-2 therapy of cancer: multiple versus single IL-2 treatment of transplanted murine colon carcinoma

Halina Kusnierczyk, Elzbieta Pajtasz-Piasecka, Jan-Willem Koten, Caspaar Bijleveld, Krzysztof Krawczyk, Willem Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

2004

Language:

english

File:

PDF, 1.82 MB

english, 2004

35

Local interleukin 2 therapy is most effective against cancer when injected intratumourally

John J. L. Jacobs, Derek Sparendam, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

2005

Language:

english

File:

PDF, 595 KB

english, 2005

36

Treatment of stage III–IV nasopharyngeal carcinomas by external beam irradiation and local low doses of IL-2

John J. L. Jacobs, Gerrit J. Hordijk, Ina M. Jürgenliemk-Schulz, Chris H. J. Terhaard, Jan W. Koten, Jan J. Battermann, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

2005

Language:

english

File:

PDF, 229 KB

english, 2005

37

Local therapy of cancer with free IL-2

Willem Den Otter, John J. L. Jacobs, Jan J. Battermann, Gerrit Jan Hordijk, Zachary Krastev, Ekaterina V. Moiseeva, Rachel J. E. Stewart, Paul G. P. M. Ziekman, Jan Willem Koten

Journal:

Cancer Immunology, Immunotherapy

Year:

2008

Language:

english

File:

PDF, 781 KB

english, 2008

38

Induction of an antibody response in mice against human papillomavirus (HPV) type 16 after immunization with HPV recombinantSalmonellastrains

M. R. L. Krul, Edwin J. Tijhaar, John A. F. W. Kleijne, Anton M. Van Loon, Mirjam G. Nievers, Hans Schipper, Liesbeth Geerse, M. Van der Kolk, Peter A. Steerenberg, Frits R. Mooi, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1996

Language:

english

File:

PDF, 137 KB

english, 1996

39

Priming of the antitumor response promotes efficacy of interleukin-2 therapy

Linda A. Everse, Monique R. Bernsen, Hub F. J. Dullens, Willem Den Otter

Journal:

Cancer Immunology, Immunotherapy

Year:

1997

Language:

english

File:

PDF, 215 KB

english, 1997

40

Interleukin-2: hope in cases of cisplatin-resistant tumours

Monique R. Bernsen, Alike W. Van Der Velden, Linda A. Everse, Hub F. J. Dullens, Willem Den Otter, A. Peter M. Heintz

Journal:

Cancer Immunology, Immunotherapy

Year:

1998

Language:

english

File:

PDF, 318 KB

english, 1998

41

Effect of local interleukin-2 treatment on spontaneous tumours of different immunogenic strength

Lucja Fiszer-Maliszewska, Willem Den Otter, Marian Mordarski

Journal:

Cancer Immunology, Immunotherapy

Year:

1999

Language:

english

File:

PDF, 103 KB

english, 1999

42

Effective cancer therapy with a single injection of interleukin-2 at the site of the tumour

Willem Den Otter, Jenny Cadée, Richard Gavhumende, Cees J. De Groot, Wim E. Hennink, Rachel Stewart

Journal:

Cancer Immunology, Immunotherapy

Year:

1999

Language:

english

File:

PDF, 57 KB

english, 1999

43

The impact of adjuvant therapy on contralateral breast cancer risk and the prognostic significance of contralateral breast cancer: a population based study in the Netherlands

Michael Schaapveld, Otto Visser, W. J. Louwman, Pax H. B. Willemse, Elisabeth G. E. de Vries, Winette T. A. van der Graaf, Renée Otter, Jan Willem W. Coebergh, Flora E. van Leeuwen

Journal:

Breast Cancer Research and Treatment

Year:

2008

Language:

english

File:

PDF, 248 KB

english, 2008

44

Oxidation of Recombinant Human Interleukin-2 by Potassium Peroxodisulfate

Jenny A. Cadée, Mies J. van Steenbergen, Cees Versluis, Albert J. R. Heck, Willy J. M. Underberg, Willem den Otter, Wim Jiskoot, Wim E. Hennink

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 169 KB

english, 2001

45

Interleukin-2-Containing Liposomes: Interaction of Interleukin-2 with Liposomal Bilayers and Preliminary Studies on Application in Cancer Vaccines

Joep J. Bergers, Willem Den Otter, Hub F. J. Dullens, Catherina T. M. Kerkvliet, Daan J. A. Crommelin

Journal:

Pharmaceutical Research

Year:

1993

File:

PDF, 1.29 MB

1993

46

Specific T-Cell Factors That Initiate Cellular Immune Responses Are Produced by CD4-, CD8-, Vβ8- Lymphocytes and Are Present in Nude Mice

Rob J. Vandebriel, Roel A. de Weger, Henk Van Loveren, Johan Garssen, Mireille N.M. Van Poppel, Dick F. Van Wichen, Willem Den Otter

Journal:

Cellular Immunology

Year:

1994

File:

PDF, 543 KB

1994

47

Growth of mycoplasma transformed tTN129 cells depends on IGF-I

Leo T. M. Van der Ven, Louk H. P. M. Rademakers, Alexander F. Angulo, Jacques C. Giltay, Iris Wills, Gerard H. Jansen, Irma M. Prinsen, Anne G. M. Rombouts, Paul J. M. Roholl, Willem Den Otter

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1993

Language:

english

File:

PDF, 769 KB

english, 1993

48

Brewer thioglycollate medium induces different exudates in guinea pigs and mice

Willem Den Otter, Jan W. De Groot, Chris D.H. Van Basten, Loek H.P.M. Rademakers, Roelof A. De Weger, Elisabeth Pels

Journal:

Experimental and Molecular Pathology

Year:

1982

Language:

english

File:

PDF, 5.70 MB

english, 1982

49

Cell surface antigen phenotypes and enzyme expression patterns of two murine T-cell lymphomas derived from early and/or mature thymus cells

Hub F.J. Dullens, Jo Hilgers, Chris D.H. Van Basten, Roelof A. De Weger, Emile De Heer, Willem Den Otter

Journal:

Leukemia Research

Year:

1982

Language:

english

File:

PDF, 232 KB

english, 1982

50

In situ crosslinked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 therapy

Gert W Bos, John J.L Jacobs, Jan Willem Koten, Sophie Van Tomme, Theo Veldhuis, Cornelus F van Nostrum, Willem Den Otter, Wim E Hennink

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 118 KB

english, 2004